Eliquis contains the active substance apixaban and belongs to a group of medicines called anticoagulants. This medicine helps prevent blood clots by blocking Factor Xa, an important element of blood clotting. Eliquis is used in adults: to prevent blood clots (deep vein thrombosis [DVT]) after a hip or knee replacement operation. After hip or knee surgery, you may be at increased risk of blood clots forming in the veins in your legs. This can cause swelling in the legs, with or without pain. If a blood clot travels from your leg to your lungs, it can impede blood flow, causing shortness of breath, with or without chest pain. This medical condition (pulmonary embolism) can be life-threatening and requires immediate medical attention. to prevent the formation of a blood clot in the heart in patients with an irregular heart beat (atrial fibrillation) and at least one additional risk factor. Blood clots can break loose, move to the brain and cause a stroke, or move to other organs avoiding proper blood supply (also known as systemic embolism). A stroke can be life-threatening and requires immediate medical attention. to treat blood clots in the veins of the legs (deep vein thrombosis) and in the blood vessels of the lungs (pulmonary embolism), and to prevent these blood clots from recurring in the blood vessels of the legs and / or or from the lungs .